Journal of Science, S. 1 (2016)

Cỡ chữ:  Nhỏ  Vừa  Lớn

Evaluation of EBNA-1 (Epsteinbarr virus nuclear antigen-1) gene prevalence in nasopharyngeal carcinoma in Vietnamese patients

LAO DUC THUAN, NGUYEN HOANG ANH TUAN, NGO DONG KHA, THIEU HONG HUE, HO TA GIAP, NGUYEN HAI CHAU, NGUYEN HUU DUNG, LE HUYEN AI THUY

Tóm tắt


   This study examined the presence of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) based on the detection of EBNA-1 (Epstein-Barr virus nuclear antigen-1) by Polymerase Chain Reaction (PCR), in Vietnamese population. Firstly, we systematically analyzed the mean of percentage weighted of the presence of EBNA-1 in previous relevant studies. Experimentally, 31 nasopharyngeal cancer biopsies and 20 healthy samples were enrolled in current to evaluate the frequency of candidate genes. As the results, the frequency of EBNA-1 was 77.42%, whereas, none of any cases of healthy samples were found to positive to target gene. The p value < 0.05 (p = 0.0001) showed that it was significant correlation between the presence of this candidate gene and nasopharyngeal cancer. Moreover, a high odds ratio (OR) and relative risk (RR) of candidate gene, (OR = 68.16, RR = 2.41) were calculated. Therefore, the detection of EBNA-1, which performed by PCR, could serve as a good supplement to early diagnosis and prognosis of NPC in Vietnamese population.

 

 


Toàn văn: PDF

Journal of Science - Ho Chi Minh City Open University